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The final weekend closure for repaving work on southbound Highway 101 in San Francisco starts at 11 p.m. Friday, according to Caltrans. All southbound lanes on the Bayshore Freeway stretch of Highway 101 known as Hospital Curve will be closed between 17th and Cesar Chavez streets until Monday at 6 a.m. Motorists can use southbound Interstate 280 as an alternate route over the weekend, Caltrans said. Northbound lanes on the Bayshore Freeway will remain open. Throughout the weekend, motorists won t be able to access the Fourth Street, Seventh Street and 10th Street on-ramps, as well as the westbound Interstate 80-northbound 101 Central Freeway Connector. The Bayshore Freeway repaving began in September on the northbound lanes, followed by work on two southbound lanes in October. This weekend, Caltrans plans to complete the project by repaving the remaining two southbound lanes. This project is part of the broader Highway 101 Bayshore Freeway (Hospital Curve) rehabilitat